Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes.

@article{Forceville2009SelenoproteinPR,
  title={Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes.},
  author={Xavier Forceville and Volker Mostert and Alessandra Pierantoni and Dominique Vitoux and Philippe Le Toumelin and Elisabeth Plouvier and Monique Dehoux and François Thuillier and Alain Combes},
  journal={European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes},
  year={2009},
  volume={43 4},
  pages={338-47}
}
BACKGROUND/AIMS Oxidative stress is involved in sepsis-related endothelium dysfunction. Selenoprotein-P (Sel-P), the main plasma selenoprotein, may have high antioxidant potential, and binds to endothelium. We hypothesize that, in septic shock, and similar syndromes such as systemic inflammatory response syndrome (SIRS), Sel-P binds massively to endothelium, causing a drop in Sel-P plasma concentration. METHODS Plasma Se, Sel-P and albumin concentrations, and glutathione peroxidase (GPx… CONTINUE READING

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