Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.

@article{Panee2007SelenoproteinHI,
  title={Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.},
  author={Jun Panee and Zoia R Stoytcheva and Wanyu Liu and Marla J. Berry},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 33},
  pages={23759-65}
}
Selenoprotein H is a recently identified member of the selenoprotein family whose function is not fully known. Previous studies from our laboratory and others showed that Drosophila melanogaster selenoprotein H is essential for viability and antioxidant defense. In this study we investigated the function of human selenoprotein H in murine hippocampal HT22 cells engineered to stably overexpress the protein. After treatment of cells with L-buthionine-(S,R)-sulfoximine to deplete glutathione… CONTINUE READING
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