Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.

  title={Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.},
  author={Sergey V. Novoselov and Gregory V. Kryukov and X Xu and Bradley A. Carlson and Dolph Lee Hatfield and Vadim N. Gladyshev},
  journal={The Journal of biological chemistry},
  volume={282 16},
The human selenoproteome consists of 25 known selenoproteins, but functions of many of these proteins are not known. Selenoprotein H (SelH) is a recently discovered 14-kDa mammalian protein with no sequence homology to functionally characterized proteins. By sensitive sequence and structure analyses, we identified SelH as a thioredoxin fold-like protein in which a conserved CXXU motif (cysteine separated by two other residues from selenocysteine) corresponds to the CXXC motif in thioredoxins… CONTINUE READING


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Publications referenced by this paper.
Showing 1-3 of 3 references

Characterization of Novel Mammalian Selenoprotein H 11968 JOURNAL OF BIOLOGICAL CHEMISTRY

B. Hofmann, H. J. Hecht, L. Flohe
J. Biol. Chem. 10.1074/jbc.M701605200 • 2002
View 1 Excerpt

Nuclear Structure and Function (Methods in Cell Biology)

M. Berrios
View 1 Excerpt

Cloning, A Laboratory Manual

J. Sambrook, E. F. Fritsch, T. Maniatis
2nd Ed., • 1989
View 1 Excerpt

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