Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors.

@article{Leibundgut2005SelenocysteineTE,
  title={Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors.},
  author={Marc Leibundgut and Christian Frick and Martin Thanbichler and August Boeck and Nenad Ban},
  journal={The EMBO journal},
  year={2005},
  volume={24 1},
  pages={11-22}
}
In all three kingdoms of life, SelB is a specialized translation elongation factor responsible for the cotranslational incorporation of selenocysteine into proteins by recoding of a UGA stop codon in the presence of a downstream mRNA hairpin loop. Here, we present the X-ray structures of SelB from the archaeon Methanococcus maripaludis in the apo-, GDP- and GppNHp-bound form and use mutational analysis to investigate the role of individual amino acids in its aminoacyl-binding pocket. All three… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Coupled tRNASec - dependent assembly of the selenocysteine decoding apparatus

  • F Zinoni, J Heider, A Böck
  • Mol Cell
  • 2003

Similar Papers

Loading similar papers…