Selenocysteine tRNA‐specific elongation factor SelB is a structural chimaera of elongation and initiation factors

@article{Leibundgut2005SelenocysteineTE,
  title={Selenocysteine tRNA‐specific elongation factor SelB is a structural chimaera of elongation and initiation factors},
  author={M. Leibundgut and C. Frick and M. Thanbichler and A. B{\"o}ck and N. Ban},
  journal={The EMBO Journal},
  year={2005},
  volume={24}
}
In all three kingdoms of life, SelB is a specialized translation elongation factor responsible for the cotranslational incorporation of selenocysteine into proteins by recoding of a UGA stop codon in the presence of a downstream mRNA hairpin loop. Here, we present the X‐ray structures of SelB from the archaeon Methanococcus maripaludis in the apo‐, GDP‐ and GppNHp‐bound form and use mutational analysis to investigate the role of individual amino acids in its aminoacyl‐binding pocket. All three… Expand
Crystal structure of the full-length bacterial selenocysteine-specific elongation factor SelB
Engineering the elongation factor Tu for efficient selenoprotein synthesis
Challenges of site-specific selenocysteine incorporation into proteins by Escherichia coli
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