Selenocysteine incorporation in Kinetoplastid: selenophosphate synthetase (SELD) from Leishmania major and Trypanosoma brucei.

@article{Sculaccio2008SelenocysteineII,
  title={Selenocysteine incorporation in Kinetoplastid: selenophosphate synthetase (SELD) from Leishmania major and Trypanosoma brucei.},
  author={Susana Andrea Sculaccio and Elisandra M. Rodrigues and Artur Torres Cordeiro and Arinos Magalh{\~a}es and Ant{\^o}nio Lu{\'i}s Braga and Eduardo Eliezer Alberto and Otavio Henrique Thiemann},
  journal={Molecular and biochemical parasitology},
  year={2008},
  volume={162 2},
  pages={165-71}
}
Selenophosphate synthetase (EC 2.7.9.3), the product of the selD gene, produces the biologically active selenium donor compound, monoselenophosphate, from ATP and selenide, for the synthesis of selenocysteine. The kinetoplastid Leishmania major and Trypanosoma brucei selD genes were cloned and the SELD protein overexpressed and purified to apparent homogeneity. The selD gene in L. major and T. brucei are respectively 1197 and 1179 bp long encoding proteins of 399 and 393 amino acids with… CONTINUE READING

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