Selenocyanates and diselenides: a new class of potent antileishmanial agents.

Abstract

Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines. Thirteen… (More)
DOI: 10.1016/j.ejmech.2011.04.054

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@article{Plano2011SelenocyanatesAD, title={Selenocyanates and diselenides: a new class of potent antileishmanial agents.}, author={Daniel Plano and Ylenia Baquedano and David Moreno-Mateos and Mar{\'i}a Teresa Carrera Font and Ant{\'o}nio Jim{\'e}nez-Ruiz and Juan Antonio Palop and Carmen Sanmart{\'i}n}, journal={European journal of medicinal chemistry}, year={2011}, volume={46 8}, pages={3315-23} }