Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion.

@article{Gopalakrishna1997SelenocompoundsIA,
  title={Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion.},
  author={Rayudu Gopalakrishna and Zhang Hui Chen and Usha Gundimeda},
  journal={Archives of biochemistry and biophysics},
  year={1997},
  volume={348 1},
  pages={37-48}
}
Since selenite and other redox-active selenocompounds can modify protein kinase C (PKC) in the test tube, we have determined whether or not this redox regulation occurs inside the cell despite having high concentrations of GSH and the role of this regulation in the inhibition of tumor promotion. By using phorbol ester-promoted JB6 epidermal cell transformation assay, the concentrations of selenite, selenocystine, and selenodiglutathione which are optimal for chemopreventive activity were… CONTINUE READING

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