Selenium toxicity: cause and effects in aquatic birds.

  title={Selenium toxicity: cause and effects in aquatic birds.},
  author={Julian E. Spallholz and David J. Hoffman},
  journal={Aquatic toxicology},
  volume={57 1-2},
There are several manners in which selenium may express its toxicity: (1) an important mechanism appears to involve the formation of CH(3)Se(minus sign) which either enters a redox cycle and generates superoxide and oxidative stress, or forms free radicals that bind to and inhibit important enzymes and proteins. (2) Excess selenium as selenocysteine results in inhibition of selenium methylation metabolism. As a consequence, concentrations of hydrogen selenide, an intermediate metabolite… CONTINUE READING


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