Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

  title={Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials},
  author={Song Mao and Aihua Zhang and Songming Huang},
It is well documented that selenium (Se) is involved in the metabolism of glucose. However, whether Se supplementation could lower the risk of type 2 diabetes mellitus (T2DM) remains elusive. We aimed to evaluate the association between Se supplementation and the risk of T2DM by performing a meta-analysis. We searched the Pubmed, Embase, and Cochrane databases from January 1990 to November 2013 to identify randomized controlled trials (RCTs) that met pre-stated inclusion criteria. Reference… 

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  • R. TabriziM. Akbari Z. Asemi
  • Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2017
Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.

Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies

A comprehensive meta-analysis of studies on the association between selenium (Se) and diabetes mellitus (DM) demonstrates that high levels of Se are associated with the presence of DM.

Toenail selenium and risk of type 2 diabetes: the ORDET cohort study.

  • M. VincetiS. Grioni S. Sieri
  • Medicine
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2015

Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies

Overall, the association between dietary factors and type 2 diabetes has been extensively studied, but few of the associations were graded as high quality of evidence.

The Association of Circulating Selenium Concentrations with Diabetes Mellitus

Circulating selenium levels were positively associated with the odds of DM, but difference in sex and age showed that seenium was independently associated with DM only in female aged <65 years.

The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

Toenail selenium levels and prevalence of dyslipidaemia among Korean adults

Abstract Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been

Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes.

Overall, selenium did not prevent colorectal adenomas and showed only modest benefit in patients with baseline advanced adenoma, with limited benefit and similar increases in T2D to other trials.



A Randomized Trial of Selenium Supplementation and Risk of Type-2 Diabetes, as Assessed by Plasma Adiponectin

Findings are reassuring as they did not show a diabetogenic effect of a six-month supplementation with selenium in this sample of elderly individuals of relatively low seenium status.

Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes

The efficacy of selenium supplementation in preventing new-onset type 2 diabetes in the NPC (Nutritional Prevention of Cancer) trial was examined, a randomized, double-blind, placebo-controlled study of 1312 participants who were recruited in 1983 to 1991 from 7 dermatology clinics in areas of low Selenium consumption of the eastern United States.

Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study

This prospective study suggests a sex-specific protective effect of higher selenium status at baseline on later occurrence of dysglycemia.

Selenium and diabetes--evidence from animal studies.

Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice.

The results of the present study show that one possible mechanism by which supranutritional selenate doses enhance insulin sensitivity in type II diabetic dbdb mice is based on the inhibition of PTPS as negative regulators of insulin signalling.

A high-selenium diet induces insulin resistance in gestating rats and their offspring.

Blood Metals Concentration in Type 1 and Type 2 Diabetics

These elements may play a role in both forms of diabetes and combined mineral supplementations could have beneficial effects.