Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide.

@article{Basini2000SeleniumSE,
  title={Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide.},
  author={Giuseppina Basini and Carlo Tamanini},
  journal={Domestic animal endocrinology},
  year={2000},
  volume={18 1},
  pages={
          1-17
        }
}
Reduction in fertility is well known to be possibly related to selenium deficiencies, even if target organ for selenium action is, at present, unclear. The present study was aimed to examine whether selenium directly influences granulosa cells. Bovine granulosa cells from different size follicles were used to investigate the effect of selenium (5 ng/ml), with or without bovine follicle-stimulating hormone (bFSH) (100 ng/ml), on proliferation and steroidogenesis. In addition, we sought to… CONTINUE READING

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