Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.


Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95% CI: 0.82-1.03 per 25 μg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (p(trend) = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (p(trend) = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82-0.98) with the association more apparent in women (p(trend) = 0.004; IRR = 0.82, 95% CI: 0.72-0.94 per 0.806 mg/L increase) than men (p(trend) = 0.485; IRR = 0.98, 95% CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.

DOI: 10.1002/ijc.29071

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@article{Hughes2015SeleniumSI, title={Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.}, author={David John Hughes and Veronika Fedirko and M. Jenab and Lutz Schomburg and Catherine M{\'e}plan and Heinz Freisling and HB Bueno-de-Mesquita and Sandra Hybsier and N Becker and Magdalena Czuban and Anne Marie Tj\onneland and Malene Outzen and Marie-Christine Boutron-Ruault and Antoine Racine and Nadia M. Bastide and Tilman Kuehn and Rudolf Kaaks and Dimitirios Trichopoulos and Antonia Trichopoulou and Pagona Lagiou and Salvatore Panico and Petra H. M. Peeters and Elisabete Weiderpass and Guri Skeie and Engeset Dagrun and M D Chirlaque and Mar{\'i}a Jos{\'e} Gonz{\'a}lez S{\'a}nchez and Eva Ardanaz and Ingrid Ljuslinder and Maria Wennberg and Kathryn E Bradbury and Paolo Vineis and Alessio Naccarati and Domenico Palli and H. Boeing and Kim Overvad and Miren Dorronsoro and Paula Jakszyn and Amanda J. Cross and Jos{\'e} Ram{\'o}n Quir{\'o}s and Magdalena Stępień and So Yeon Joyce Kong and Talita Duarte-Salles and Elio Riboli and John E. Hesketh}, journal={International journal of cancer}, year={2015}, volume={136 5}, pages={1149-61} }