Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.

@article{Hwang2006SeleniumRC,
  title={Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.},
  author={Jin-Taek Hwang and Young Min Kim and Y. -J. Surh and Haing Woon Baik and Seong-Kyu Lee and Joohun Ha and Ock Jin Park},
  journal={Cancer research},
  year={2006},
  volume={66 20},
  pages={10057-63}
}
Epidemiologic and experimental evidences indicate that selenium, an essential trace element, can reduce the risk of a variety of cancers. Protection against certain types of cancers, particularly colorectal cancers, is closely associated with pathways involving cyclooxygenase-2 (COX-2). We found that AMP-activated protein kinase (AMPK), which functions as a cellular energy sensor, mediates critical anticancer effects of selenium via a COX-2/prostaglandin E(2) signaling pathway. Selenium… CONTINUE READING