Selenium protects cerebral ischemia in rat brain mitochondria

  title={Selenium protects cerebral ischemia in rat brain mitochondria},
  author={Mubeen Ahmad Ansari and Abdullah Shafique Ahmad and Muzamil Ahmad and Sofiyan Salim and Seema Yousuf and Tauheed Ishrat and Fakhrul Islam},
  journal={Biological Trace Element Research},
Normal cellular metabolism produces oxidants that are neutralized by the cells' antioxidant enzymes and antioxidants taken from outside. An imbalance between oxidant and antioxidant has been postulated to lead to the neurodegeneration in the ischemic condition. In this study, we have demonstrated the prevention or slowdown of neuronal injury in middle cerebral artery occlusion (MCAO) by sodium selenite. Rats were pretreated with 0.05, 0.1, and 0.2 mg/kg body wt of sodium selenite for 7 d. The… CONTINUE READING
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