Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.

@article{Penglase2014SeleniumPD,
  title={Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.},
  author={Samuel James Penglase and Kristin Hamre and Staale Ellingsen},
  journal={Free radical biology & medicine},
  year={2014},
  volume={75},
  pages={95-104}
}
Selenium (Se) is an essential nutrient required by Se-dependent proteins, termed selenoproteins. The selenoprotein family is small but diverse and includes key proteins in antioxidant, redox signaling, thyroid hormone metabolism, and protein folding pathways. Methylmercury (MeHg) is a toxic environmental contaminant that affects seafood safety. Selenium can reduce MeHg toxicity, but it is unclear how selenoproteins are affected in this interaction. In this study we explored how Se and MeHg… CONTINUE READING