Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

@inproceedings{Mehta2012SeleniumPM,
  title={Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia},
  author={Suresh L. Mehta and S Chandrika Kumari and Natalia N. Mendelev and P Andy Li},
  booktitle={BMC Neuroscience},
  year={2012}
}
Mitochondrial dysfunction is one of the major events responsible for activation of neuronal cell death pathways during cerebral ischemia. Trace element selenium has been shown to protect neurons in various diseases conditions. Present study is conducted to demonstrate that selenium preserves mitochondrial functional performance, activates mitochondrial biogenesis and prevents hypoxic/ischemic cell damage. The study conducted on HT22 cells exposed to glutamate or hypoxia and mice subjected to 60… CONTINUE READING
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