Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans.


Selenium is an essential micronutrient required for cellular antioxidant systems, yet at higher doses it induces oxidative stress. Additionally, in vertebrates environmental exposures to toxic levels of selenium can cause paralysis and death. Here we show that selenium-induced oxidative stress leads to decreased cholinergic signaling and degeneration of… (More)
DOI: 10.1016/j.neuro.2012.04.019