Selenium-enriched garlic inhibits the early stage but not the late stage of mammary carcinogenesis.

@article{Ip1996SeleniumenrichedGI,
  title={Selenium-enriched garlic inhibits the early stage but not the late stage of mammary carcinogenesis.},
  author={Clement Ip and Donald J. Lisk and Henry J. Thompson},
  journal={Carcinogenesis},
  year={1996},
  volume={17 9},
  pages={
          1979-82
        }
}
Previous work has shown that the efficacy of cancer prevention by selenium-enriched garlic (Se-garlic) is primarily dependent on the action of selenium. Additionally, supplementation of Se-garlic inhibited the post-initiation phase of mammary carcinogenesis when it was given continuously to the animals. In this report, experiments were carried out in which treatment with the Se-garlic was started after carcinogen dosing (DMBA or MNU) but was restricted to either the early or late stage of… 
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76 Citations
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76 Citations

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Citation Type

Effect on an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention.
TLDR
It is hypothesized that the Se-garlic extract, in part via the action of Se-methylselenocysteine, is able to inhibit tumorigenesis by suppressing the proliferation and reducing the survival of the early transformed cells.
Methyl-Selenium Compounds Inhibit Prostate Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate Model with Survival Benefit
TLDR
These selenium compounds may effectively inhibit this model of prostate cancer carcinogenesis using the transgenic adenocarcinoma mouse prostate (TRAMP) model.
In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: lack of involvement of gadd genes
TLDR
These experiments showed the induction of cancer epithelial cell apoptosis and inhibition of cell proliferation by Se in vivo through the potential involvement of cyclin D1, P27Kip1, and c-Jun NH2-terminal kinase pathways, and cast doubt on the three gadd genes as mediators of Se action in vivo.
Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention.
TLDR
Comparison of biological activities of Se-garlic and Se-yeast was compared to elucidate how their disposition in tissues might account for the differences in cancer chemopreventive activity and the metabolism of these two compounds is discussed.
Selenium as a chemopreventive agent in experimentally induced colon carcinogenesis.
TLDR
The study suggests the antioxidative potential of selenium is a major factor in providing protection from development of experimentally induced colon carcinogenesis.
Garlic and Cancer
TLDR
While research on garlic is promising, the outcome can not be directly translated in specific recommendations for garlic consumption, however this outcome must sustain the general recommendation of consuming daily a variety of vegetables and fruits.
Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl.
TLDR
Dietary selenium, depending on chemical form, can reduce aromatic amine-induced colon carcinogenesis, and this effect is associated with reduction in the incidence of several cancers, including colorectal cancer.
Cancer-protective properties of high-selenium broccoli.
TLDR
It is demonstrated that the cancer-protective effect of Se in high- Se broccoli extends to mammary cancer and the protective forms of broccoli against colon cancer include high-Se broccoli sprouts.
Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation.
Chemopreventive Doses of Methylselenocysteine Alter Circadian Rhythm in Rat Mammary Tissue
TLDR
Observations suggest that Per2 is an important target of methylselenocysteine during chemoprevention in N-nitroso-N-methylurea–induced rat mammary carcinogenesis, and for the first time provide a link between chemopRevention and circadian rhythm.
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References

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Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium.
TLDR
The ability of the high-selenium garlic to protect against tumorigenesis is primarily dependent on increased intake of selenium provided by the vegetable.
Mammary cancer prevention by regular garlic and selenium-enriched garlic.
TLDR
The study demonstrated the feasibility of achieving cancer prevention with the use of a selenium-rich food system and showed that diallyl disulfide was more active than dially l sulfide or allyl methyl sulfide.
Effect on an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention.
TLDR
It is hypothesized that the Se-garlic extract, in part via the action of Se-methylselenocysteine, is able to inhibit tumorigenesis by suppressing the proliferation and reducing the survival of the early transformed cells.
Synergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats.
TLDR
It is apparent that systemic suppression of lipid peroxidation by vitamin E subsequent to a carcinogenic insult is not sufficient to inhibit tumor formation, and vitamin E may be able to provide a more favorable climate against oxidant stress, thereby potentiating the action of selenium via some other mechanism.
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TLDR
The high-selenium garlic/onion might provide an ideal system for delivering selenium-substituted analogs in a food form for cancer prevention because they expressed a good range of anticancer activity and could be easily adapted for human consumption on a regular basis.
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TLDR
Dietary CLA between 0.05 and 0.5% was found to produce a dose-dependent inhibition in mammary tumor yield when fed chronically to rats treated with a lower dose of 7,12-dimethylbenz(a)anthracene.
Characterization of tissue selenium profiles and anticarcinogenic responses in rats fed natural sources of selenium-rich products.
TLDR
The experiments suggested that the high-selenium garlic and onion might have some unique attributes, and their ingestion did not lead to an exaggerated accumulation of tissue selenium, a concern that was shared by both selenomethionine and Brazil nut.
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TLDR
It was proposed that the justification for carrying out human intervention trials with Se to prevent cancer should be at best marginal or in the pharmacologic range, and levels similar to the intakes of populations residing in regions naturally high in Se were suggested.
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