Selenium-deficient diet induces renal oxidative stress and injury via TGF-beta1 in normal and diabetic rats.

@article{Reddi2001SeleniumdeficientDI,
  title={Selenium-deficient diet induces renal oxidative stress and injury via TGF-beta1 in normal and diabetic rats.},
  author={A. Subbarami Reddi and Jaya S Bollineni},
  journal={Kidney international},
  year={2001},
  volume={59 4},
  pages={1342-53}
}
BACKGROUND Oxidative stress has been implicated in the pathogenesis of diabetic nephropathy. Although glucose itself can initiate oxidative stress, deficiency of essential trace elements such as selenium (Se) may exacerbate this oxidative stress in diabetic rats. The mechanism by which Se deficiency causes oxidative stress and renal injury is not completely understood. This study tested the hypothesis that Se deficiency induces renal oxidative stress and renal injury via transforming growth… CONTINUE READING

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