Selenium-containing enzymes in mammals: Chemical perspectives
@article{Roy2005SeleniumcontainingEI, title={Selenium-containing enzymes in mammals: Chemical perspectives}, author={Gouriprasanna Roy and Bani Kanta Sarma and Prasad P. Phadnis and Govindasamy Mugesh}, journal={Journal of Chemical Sciences}, year={2005}, volume={117}, pages={287-303} }
The chemical and biochemical route to the synthesis of the 21st amino acid in living systems, selenocysteine, is described. The incorporation of this rare amino acid residue into proteins is described with emphasis on the role of monoselenophosphate as selenium source. The role of selenocysteine moiety in natural mammalian enzymes such as glutathione peroxidase (GPx), iodothyronine deiodinase (ID) and thioredoxin reductase (TrxR) is highlighted and the effect of other amino acid residues…
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