Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage.

@article{Campbell2007SeleniumAS,
  title={Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage.},
  author={Leigh Campbell and Forbes A. Howie and J Richard Arthur and Fergus Nicol and Geoff J. Beckett},
  journal={Nutrition},
  year={2007},
  volume={23 2},
  pages={138-44}
}
OBJECTIVE We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells. The effectiveness of these agents to protect cells against peroxidative damage was also assessed. METHODS EAhy926 cells were supplemented with 40 nM of selenite and/or sulforaphane (10 microM) for 72 h and the expression of TR-1, GPX-1, and GPX-4 was assessed. Parallel cultures of selenium- and sulforaphane… CONTINUE READING
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