Selenium and brain function: a poorly recognized liaison.

  title={Selenium and brain function: a poorly recognized liaison.},
  author={Ulrich Schweizer and Anja Ursula Br{\"a}uer and Josef Koehrle and Robert Nitsch and Nicolai Savaskan},
  journal={Brain research. Brain research reviews},
  volume={45 3},
Molecular biology has recently contributed significantly to the recognition of selenium (Se)2 and Se-dependent enzymes as modulators of brain function. Increased oxidative stress has been proposed as a pathomechanism in neurodegenerative diseases including, among others, Parkinson's disease, stroke, and epilepsy. Glutathione peroxidases (GPx), thioredoxin reductases, and one methionine-sulfoxide-reductase are selenium-dependent enzymes involved in antioxidant defense and intracellular redox… CONTINUE READING
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