Selenium Modulates Oxidative Stress-Induced Cell Apoptosis in Human Myeloid HL-60 Cells Through Regulation of Calcium Release and Caspase-3 and -9 Activities

@article{Uguz2009SeleniumMO,
  title={Selenium Modulates Oxidative Stress-Induced Cell Apoptosis in Human Myeloid HL-60 Cells Through Regulation of Calcium Release and Caspase-3 and -9 Activities},
  author={Abd{\"u}lhadi Cihangir Uguz and Mustafa Nazıroğlu and Javier Espino and Ignacio Bejarano and David Montes Gonz{\'a}lez and Ana Rodriguez and Jos{\'e} A Pariente},
  journal={Journal of Membrane Biology},
  year={2009},
  volume={232},
  pages={15-23}
}
Selenium is an essential chemopreventive antioxidant element to oxidative stress, although high concentrations of selenium induce toxic and oxidative effects on the human body. However, the mechanisms behind these effects remain elusive. We investigated toxic effects of different selenium concentrations in human promyelocytic leukemia HL-60 cells by evaluating Ca2+ mobilization, cell viability and caspase-3 and -9 activities at different sample times. We found the toxic concentration and toxic… 
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