Selenium Biochemistry

  title={Selenium Biochemistry},
  author={Thressa Campbell Stadtman},
  pages={915 - 922}
The toxicity of selenium to animals and plants has been known and extensively documented since the 1930's, but it is only during the past 15 years that selenium has also been shown to be an essential micronutrient for animals and bacteria. Very little is known about the specific role or roles of selenium and, to date, there are only three enzyme-catalyzed reactions that have been shown to require the participation of a selenium-containing protein. These are the reactions catalyzed by (i… 
Metabolic aspects of selenium action and toxicity.
The nutritional observations, on which the activity of selenium is based, are briefly reviewed, and the interactions of the trace element with vitamin E, polyunsaturated fatty acids, and sulfur amino
Selenium-containing tRNA of a higher plant.
The distribution of 75Se in brains of selenium‐deficient rats
In a recent study of selenium in tissues of deficient rats, BROWN & BURK (1973) found a remarkable degree of 75Se retention in brain and in testis, which suggested to us the existence of biological functions for seenium other than participation in GSH peroxidase activity.
Genetic Adaptation and Selenium Uptake in Vertebrates
The transport of selenium has been under evolutionary constraint in fishes, whereas it has evolved neutrally in mammals and other non-fish lineages, and its content in the diet of humans and other vertebrates is often inadequate throughout the world.
Selenium biochemistry chemical and physical studies
A brief discussion of the vast and increasingly important area of organoselenium chemistry is presented as it relates to the biochemistry of this element. Organo selenoamino acids are the basic
Bacteria Versus Selenium: A View from the Inside Out
Several biotechnological applications, such as the production of functional materials and the biofortification of crop species using Se-utilizing bacteria, are presented in this chapter.


Selenomethionine in Enzymatic Transmethylations
It has been shown that selenium is an essential trace element for the rat and is stimulatory, if not essential, for the growth of certain plants, and the structure of the essential seenium compound or compounds remains to be established.
Hemoglobin catabolism. II. The protection of hemoglobin from oxidative breakdown in the intact erythrocyte.
In the present studies, catalase and the peroxidase-GSH system of intact erythrocytes are shown to protect hemoglobin from oxidative breakdown brought about in the presence of ascorbic acid.
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.