Selenium: a double-edged sword for defense and offence in cancer

@article{Brozmanov2010SeleniumAD,
  title={Selenium: a double-edged sword for defense and offence in cancer},
  author={Jela Brozmanov{\'a} and Dominika M{\'a}nikov{\'a} and Viera Vl{\vc}kov{\'a} and Miroslav Chovanec},
  journal={Archives of Toxicology},
  year={2010},
  volume={84},
  pages={919-938}
}
Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by Se metabolites, modulation of cell cycle and apoptosis, and effect on DNA repair have all been proposed. Despite the unsupported results of the last SELECT trial, the cancer… CONTINUE READING
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