Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna

@article{Ganther1972SeleniumRT,
  title={Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna},
  author={Howard E. Ganther and Cheryl A. Goudie and Milton L. Sunde and M. J. Kopecky and P A Wagner and Sang-Hwan Oh and William G. Hoekstra},
  journal={Science},
  year={1972},
  volume={175},
  pages={1122 - 1124}
}
Japanese quail given 20 parts per million of mercury as methylmercury in diets containing 17 percent (by weight) tuna survived longer than quail given this concentration of methylmercury in a corn-soya diet. Tuna has a relatively high content of selenium and tends to accumulate additional selenium when mercury is present. A content of selenium in the diet comparable to that supplied by tuna decreased methylmercury toxicity in rats. Selenium in tuna, far from being a hazard in itself, may lessen… Expand
Dietary selenium protection of methylmercury intoxication of Japanese quail
TLDR
Selenium, as sodium selenite, added at 5 ppm to purified diets of Japanese quail protected against methylmercury intoxication, and residues in liver, kidney, and brain are higher in male than female quail, which does not indicate that birds will show evidence of methylMERcury toxicosis. Expand
Effect of selenite on the uptake of methylmercury in cod (Gadus morhua)
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The present study was designed to determine the possible interaction of methylmercury and selenium in different tissues of cod by means of feeding diets supplemented with nontoxic levels of the elements. Expand
Mercury metabolism in Japanese quail. I. The effect of dietary mercury and selenium on their tissue distribution.
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Selenium addition had no effect on the mercury concentration in kidney, brain, or blood but did tend to increase the concentration of mercury in the livers of the methylmercuric chloride-treated birds, while all other tissue selenium levels were unaffected by the addition of mercury. Expand
Efficacy of selenium in tuna and selenite in modifying methylmercury intoxication.
TLDR
Efficacy of selenium in tuna, as compared to that of seenium in selenite, was roughly equivalent in growth rate but approximately half as effective in preventing neurological manifestations, warranting further investigations upon the protective activity of naturally occurring selenum against methylmercury toxicity. Expand
Modification of a selenium toxicity in chicks by dietary silver and copper.
TLDR
The results of these experiments suggest that silver modifies selenium toxity both by interfering with seenium absorption and by causing the accumulation of a nondeleterious selenum compound in the tissues. Expand
Dietary interaction between methylmercury, selenium, arsenic, and sulfur amino acids in Japanese quail.
TLDR
Evidence is provided that As added alone in the form of arsenite has little effect on methylmercury toxicity but altered the ability of selenite to modify methylmerCury toxicity. Expand
Complementary accumulation of selenium and mercury in fish muscle.
TLDR
The concentrations of total selenium and total mercury in the muscle of striped mullet from four stations in the Northern Tyrrhenian Sea and one in the Black Sea were analyzed and suggested that Se-Hg receptors exist and increase with the age of the animal. Expand
Comparative effects of selenium on metabolism on methylmercury by chickens and quail: tissue distribution and transfer into eggs.
  • J. Sell
  • Biology, Medicine
  • Poultry science
  • 1977
TLDR
The data indicate that major differences between chickens and quail exist with respect to the influence of SE on Hg metabolism, and the total Hg content of eggs and tissues, as determined on selected samples, closely paralleled 203 Hg levels found. Expand
A role of selenium against methylmercury toxicity
TLDR
Evidence is presented that selenite can release methylmercury from its linkage with proteins and thereby influence its tissue distribution and that inorganic selenium prevents growth inhibition as well as mortality and neurotoxicity due to methylMERcury given simultaneously in the diet of Japanese quail and rats. Expand
Importance of Molar Ratios in Selenium-Dependent Protection Against Methylmercury Toxicity
TLDR
Hg to Se molar ratios provide a more reliable and comprehensive criteria for evaluating risks associated with MeHg exposure and support the hypothesis that Hg-dependent sequestration of Se is a primary mechanism of Hg toxicity. Expand
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