Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells.

@article{Conley2004SeleniumsEO,
  title={Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells.},
  author={Shannon M Conley and Roberta L. Bruhn and Parham V Morgan and William Daniel Stamer},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 2},
  pages={
          473-9
        }
}
PURPOSE Because of the observed increase in incidence of glaucoma among some individuals taking selenium as a dietary supplement, the present study was undertaken to investigate mechanisms of selenium-induced changes in homeostasis of human trabecular meshwork (HTM) cells. Specifically, the impact of selenium on matrix metalloproteinases (MMPs), their inhibitors (tissue inhibitors of metalloproteinases; TIMPs), and the second messengers that regulate MMP expression was investigated in an HTM… CONTINUE READING
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