Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells.

@article{Xiang2008SeleniteRS,
  title={Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells.},
  author={Nong Xiang and Rui Zhao and Guoqing Song and Weixiong Zhong},
  journal={Carcinogenesis},
  year={2008},
  volume={29 11},
  pages={
          2175-81
        }
}
DNA hypermethylation is a common epigenetic alteration in human prostate cancer and is considered to contribute to development of this disease. Accumulating data suggest that dietary factors may alter cancer risk by modifications of epigenetic processes in the cell. The present study was designed to investigate whether selenium (Se) would alter epigenetic events to regulate methylation-silenced genes in human prostate cancer cells. DNA methylation, histone modifications and gene expression were… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2007

Expression of p 53 enhances seleniteinduced superoxide radical production and apoptosis in human prostate cancer cells

J. Nakayama
  • Cancer Res .
  • 2006