Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1.

@article{Lee2003SeleniteinducedSO,
  title={Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1.},
  author={Y S Lee and Yun-Chi Tang and Y Chen and Chiuan-Mei Wong and A P Tsou},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 41},
  pages={
          39615-24
        }
}
Selenium has been shown to sustain the growth of selected human hepatocellular carcinoma cell lines under serum-free conditions, but the detailed mechanism remained undetermined. In the present study, the molecular mechanism(s) involving sodium selenite (Na2SO3, Se) as a survival agent were determined. Selenite not only protects HuH7 cells from serum deprivation-induced apoptosis, it also supports its long-term growth in sodium selenite (10(-7)m) supplemented serum-free medium. The anti… CONTINUE READING

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