Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis.

  title={Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis.},
  author={Dale J. Lange and Peregrine L Murphy and Beverly Diamond and Vicki Appel and Eugene C. Lai and David E. Sahn Stephen D. Younger and Stanley H. Appel},
  journal={Archives of neurology},
  volume={55 1},
BACKGROUND The cause of amyotrophic lateral sclerosis (ALS) is not known, and there is no effective treatment. Cell death may be caused by oxidative damage. Selegiline hydrochloride (Eldepryl) is a monoamine oxidase-B inhibitor with antioxidant properties. OBJECTIVE To determine if selegiline affects the clinical course of patients with ALS. DESIGN Six-month, double-blind, placebo-controlled study of 133 patients with classical ALS and symptoms for less than 3 years. The primary end point… CONTINUE READING


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