Selegiline Transdermal System In the Treatment of Major Depressive Disorder
@article{Frampton2012SelegilineTS, title={Selegiline Transdermal System In the Treatment of Major Depressive Disorder}, author={James E. Frampton and Greg L. Plosker}, journal={Drugs}, year={2012}, volume={67}, pages={257-265} }
Abstract▴ The monamine oxidase (MAO) inhibitor selegiline is selective for MAO-B at the low oral dosages used in the treatment of Parkinson’s disease. However, MAO-A is also inhibited at the high oral dosages needed to effectively treat depression (not an approved indication), necessitating a tyramine-restricted diet. The selegiline transdermal system was designed to deliver antidepressant drug concentrations to the CNS, without substantially impairing small intestine MAO-A activity. At the…
18 Citations
Selegiline Transdermal System: In the Treatment of Major Depressive Disorder
- Medicine, PsychologyDrugs
- 2012
Data from three randomized controlled trials showed a significantly better efficacy of STS in the treatment of unipolar major depression in comparison with placebo during 6–8 weeks of treatment, and one long-term randomized controlled trial demonstrated the efficacy of theSTS in relapse prevention of un bipolar depression over 1 year.
The pharmacokinetic evaluation of selegiline ODT for the treatment of Parkinson's disease
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The only well-justified advantage of the ODT formulation is its convenient use in parkinsonian patients who have difficulties in swallowing the regular formulation, and it suggests that the metabolites do not participate significantly in the therapeutic or toxic effects of selegiline.
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Clinicians should be hypervigilant to this probable drug-drug interaction between warfarin and selegiline when initiating either therapy in a patient maintained on the opposing drug.
Original Article Interaction Between Warfarin and Transdermal Selegiline: First Case Report and Literature Review
- Medicine
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Clinicians should be hypervigilant to this probable drug-drug interaction between warfarin and selegiline when initiating either therapy in a patient maintained on the opposing drug.
Structure‐Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases
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In this review, progress in the detecting and inhibiting of MAOs and their applications in mechanism exploration and treatment of neurotransmitter‐related disorders is summarized.
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An overview of the neuroprotective/neurorescue properties of these multifaceted drugs is presented and focuses on phenelzine, (-)-deprenyl, rasagiline, ladostigil, tranylcypromine, moclobemide, and clorgyline and their possible neuroprot protective mechanisms.
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A significant increase in brain dopamine, reduction in monoamine oxidase B level, increase in catalase activity and level of reduced glutathione upon treatment with SNT-gel indicated its effectiveness which was also supported by histopathology results, suggesting nasal thermosensitive gel holds better potential for brain targeting in Parkinson's disease over the conventional nasal or oral formulations.
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Transdermal delivery of ethosomes as a novel vesicular carrier for paroxetine hydrochloride: In vitro evaluation and In vivo study
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