Selegiline Transdermal System In the Treatment of Major Depressive Disorder

@article{Frampton2012SelegilineTS,
  title={Selegiline Transdermal System In the Treatment of Major Depressive Disorder},
  author={J. Frampton and G. Plosker},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={257-265}
}
  • J. Frampton, G. Plosker
  • Published 2012
  • Medicine
  • Drugs
  • Abstract▴ The monamine oxidase (MAO) inhibitor selegiline is selective for MAO-B at the low oral dosages used in the treatment of Parkinson’s disease. However, MAO-A is also inhibited at the high oral dosages needed to effectively treat depression (not an approved indication), necessitating a tyramine-restricted diet. The selegiline transdermal system was designed to deliver antidepressant drug concentrations to the CNS, without substantially impairing small intestine MAO-A activity. At the… CONTINUE READING
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