Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

@article{Shimada1998SelectivityOP,
  title={Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.},
  author={Tsutomu Shimada and Hiroshi Yamazaki and Maryam K. Foroozesh and Nancy Eddy Hopkins and William L. Alworth and F Peter Guengerich},
  journal={Chemical research in toxicology},
  year={1998},
  volume={11 9},
  pages={1048-56}
}
Human cytochrome P450s 1A1, 1A2, and 1B1 are known to have overlapping substrate specificities. All are regulated in part by the Ah locus; P450 1A2 is expressed essentially only in liver, but P450s 1A1 and 1B1 are both expressed in many extrahepatic tissues. Twenty-five polycyclic hydrocarbons, many containing acetylenic side chains, were examined as inhibitors of the three enzymes using 7-ethoxyresorufin O-deethylation as the enzyme assay in all cases. Several compounds were inhibitory at low… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
53 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

Similar Papers

Loading similar papers…