Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

@article{Shimada1998SelectivityOP,
  title={Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.},
  author={Tsutomu Shimada and Hiroshi Yamazaki and Maryam Foroozesh and Nancy Eddy Hopkins and William L. Alworth and F. Peter Guengerich},
  journal={Chemical research in toxicology},
  year={1998},
  volume={11 9},
  pages={
          1048-56
        }
}
Human cytochrome P450s 1A1, 1A2, and 1B1 are known to have overlapping substrate specificities. All are regulated in part by the Ah locus; P450 1A2 is expressed essentially only in liver, but P450s 1A1 and 1B1 are both expressed in many extrahepatic tissues. Twenty-five polycyclic hydrocarbons, many containing acetylenic side chains, were examined as inhibitors of the three enzymes using 7-ethoxyresorufin O-deethylation as the enzyme assay in all cases. Several compounds were inhibitory at low… 

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