Selectivity of metoclopramide for endocrine versus renal effects of dopamine in normal humans.

@article{Blumberg1988SelectivityOM,
  title={Selectivity of metoclopramide for endocrine versus renal effects of dopamine in normal humans.},
  author={A L Blumberg and Jeffrey W Dubb and N L Allison and Z Aldins and K Ramey and Robert M. Stote},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={11 2},
  pages={181-6}
}
The purpose of the present study was to evaluate the effect on renal function of dopamine (low dose, 2 micrograms/kg/min) inhibition by a low-dose infusion of metoclopramide. Prolactin and aldosterone levels were measured to assess metoclopramide's endocrine effects. Six salt-loaded subjects were studied by standard renal clearance techniques during water diuresis. Dopamine infusion produced an increase in renal plasma flow, fractional excretion of sodium, osmolar and free water clearances… CONTINUE READING

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