Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels.

@article{Uneyama1999SelectivityOD,
  title={Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels.},
  author={Hisayuki Uneyama and Hisashi Uchida and Tomoyuki Konda and Ryota Yoshimoto and Norio Akaike},
  journal={European journal of pharmacology},
  year={1999},
  volume={373 1},
  pages={93-100}
}
The blocking effects of cilnidipine and other dihydropyridines on L-type cardiac Ca2+ channels (I(Ca,L)) and N-type sympathetic Ca2+ channel currents (I(Ca,N)) were studied using a whole-cell patch-clamp technique. At -80 mV, cilnidipine had little inhibitory effect below concentrations of 1 microM on I(Ca,L) (IC50 value; 17 microM). However, 1 microM cilnidipine strongly shifted the steady-state inactivation curve of I(Ca,L) toward negative potentials without changing the current-voltage… CONTINUE READING

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