Selectivity of commonly used inhibitors of clathrin-mediated and caveolae-dependent endocytosis of G protein-coupled receptors.

@article{Guo2015SelectivityOC,
  title={Selectivity of commonly used inhibitors of clathrin-mediated and caveolae-dependent endocytosis of G protein-coupled receptors.},
  author={Shuohan Guo and Xiaohan Zhang and Mei Zheng and Xiaowei Zhang and Chengchun Min and Zengtao Wang and Seung Hoon Cheon and Min-Ho Oak and Seung-Yeol Nah and Kyeong-Man Kim},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1848 10 Pt A},
  pages={2101-10}
}
Among the multiple G protein-coupled receptor (GPCR) endocytic pathways, clathrin-mediated endocytosis (CME) and caveolar endocytosis are more extensively characterized than other endocytic pathways. A number of endocytic inhibitors have been used to block CME; however, systemic studies to determine the selectivity of these inhibitors are needed. Clathrin heavy chain or caveolin1-knockdown cells have been employed to determine the specificity of various chemical and molecular biological tools… CONTINUE READING