Selectivity of Sterically Fixed Tryptamine and 5‐Methoxytryptamine Derivatives for Serotonin Receptor Subtypes, II :Structure‐Activity Relationships and in vitro Pharmacology of N‐Alkyl‐ and N,N‐Dialkyl‐3‐indolylbicyclo‐[2.2.1]‐heptane‐2‐amines

@article{Elz1993SelectivityOS,
  title={Selectivity of Sterically Fixed Tryptamine and 5‐Methoxytryptamine Derivatives for Serotonin Receptor Subtypes, II :Structure‐Activity Relationships and in vitro Pharmacology of N‐Alkyl‐ and N,N‐Dialkyl‐3‐indolylbicyclo‐[2.2.1]‐heptane‐2‐amines},
  author={Sigurd Elz and Hans Zimmermann and Klaus Rehse},
  journal={Archiv der Pharmazie},
  year={1993},
  volume={326}
}
Twentyfour norbornane analogues of tryptamine and 5‐methoxytryptamine were investigated for affinity at 5‐HT2 receptors of the rat tail artery and proved to be weak non‐competitive antagonists of 5‐HT. Compound 12 which displayed a marked depression of the concentration‐effect curves, was examined for potential interaction with the allosteric binding site of the 5‐HT2 receptor. The effects elicited by 12, in the presence and absence of the allosteric activator ketanserin, were atpyical and must… 
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