Selectivity in neurotrophin signaling: theme and variations.

  title={Selectivity in neurotrophin signaling: theme and variations.},
  author={Rosalind A. Segal},
  journal={Annual review of neuroscience},
Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal survival factors, neurotrophins elicit many biological effects, ranging from proliferation to synaptic modulation to axonal pathfinding. Recent data indicate that the nature of the signaling cascades activated by neurotrophins, and the biological responses that ensue, are specified not only by the ligand itself but also by the temporal… CONTINUE READING
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