Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding.

@article{Boiten2019SelectivityIC,
  title={Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding.},
  author={Walter A. Boiten and Richard W J Helder and Jeroen van Smeden and Joke A. Bouwstra},
  journal={Biochimica et biophysica acta. Molecular and cell biology of lipids},
  year={2019},
  volume={1864 9},
  pages={
          1206-1213
        }
}
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The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models.
Comprehensive characterization and simultaneous analysis of overall lipids in reconstructed human epidermis using NPLC/HR-MSn: 1-O-E (EO) Cer, a new ceramide subclass
TLDR
The lipidomic approach offers a direct access to epidermis biomarkers, and a new subclass of ceramides, 1-O-Acyl Omega-linoleoyloxy ceramide, has been highlighted, which can contribute to the skin barrier.
Human skin equivalents: impaired barrier function in relation to the lipid and protein properties of the stratum corneum.
Anatomy of the human skin
Multitargeted Approach for the Optimization of Morphogenesis and Barrier Formation in Human Skin Equivalents
TLDR
A leading optimization approach substantially improved the epidermal morphogenesis, barrier formation, and functionality in the full-thickness models (FTMs), which therefore better resembled native human skin.
Stratum Corneum Function: A Structural Study with Dynamic Synchrotron X-ray Diffraction Experiments.
TLDR
It is proposed that the liquid state region is the main pathway for hydrophobic drugs with a small molecular weight in connection with the so-called 500 Da rule.
The role of ceramides in skin homeostasis and inflammatory skin diseases.
THE CORNIFIED ENVELOPE BOUND CERAMIDE FRACTION IS ALTERED IN ATOPIC DERMATITIS PATIENTS.

References

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TLDR
Data indicate that involucrin, envoplakin, periplakin, and possibly other structural proteins serve as substrates for the attachment of ceramides by ester linkages to the CE for barrier function in human epidermis.
Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing.
TLDR
Gene expression profiling of Ugcg-mutant skin revealed a subset of differentially expressed genes involved in lipid signaling and epidermal differentiation/proliferation, correlating to human skin diseases such as psoriasis and atopic dermatitis.
Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function.
TLDR
Results provide the first direct evidence for the importance of omega-OHCer for epidermal permeability function, and suggest further that acylCer and/or corneocyte lipid envelope are required elements in permeability barrier homeostasis.
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TLDR
The results suggest that the amount of covalently bound ceramides is highly correlated with the barrier function of the skin, and that covalent bound cer amides play an important role in the formation of lamellar structures, and are involved in the maintenance of the barrierfunction of theskin.
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TLDR
Results demonstrate that the production of pSAP, and presumably mature sphingolipid activator protein generation, is required for normal epidermal barrier formation and function and suggests that deglucosylation to ω-OH-Cer is not a requisite step prior to covalent attachment of lipid to cornified envelope proteins.
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TLDR
It is demonstrated that human stratum corneum contains covalently bound lipids accounting for 1.4% of the dry weight of the tissue, and it is suggested that the principal function of the covalent bound lipid is the formation of a lipid envelope on the outer surface of the keratinized cells.
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TLDR
In reconstructed epidermis the content of linoleic acid in all three acylceramides fraction was significantly lower, which together with a lower content of free fatty acids may explain the differences between native and reconstructed tissue in stratum corneum lipid organization observed earlier by X-ray diffraction.
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TLDR
Results show that all of the omega-hydroxyceramides of corneocyte lipid envelopes are attached to protein through their omega-Hydroxyl groups.
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