Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors.

@article{Pintor1996SelectivityAA,
  title={Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors.},
  author={Jes{\'u}s Pintor and Brian F. King and M Teresa Miras-Portugal and Geoffrey Burnstock},
  journal={British journal of pharmacology},
  year={1996},
  volume={119 5},
  pages={1006-12}
}
1. Adenine dinucleotides (Ap3A, x = 2-6) are naturally-occurring polyphosphated nucleotidic substances which are found in the CNS and are known to be released in a calcium-dependent manner from storage vesicles in brain synaptosomes. The selectivity and activity of adenine dinucleotides for neuronally-derived recombinant P2 purinoceptors were studied using P2X2 and P2Y1 subtypes expressed in Xenopus oocytes. 2. For the P2Y1 subtype derived from chick brain, Ap3A was equipotent and as active as… CONTINUE READING