Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach

@inproceedings{Pessoa2018SelectivityAO,
  title={Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach},
  author={Marco Tulio C. Pessoa and Silmara L. G. Alves and Alex Gutterres Taranto and Jos{\'e} A F P Villar and Gustavo Blanco and Leandro A Barbosa},
  booktitle={Journal of enzyme inhibition and medicinal chemistry},
  year={2018}
}
Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzylidene digoxin derivatives) with substitutions in the lactone… CONTINUE READING