Selectivity Changes during Activation of Mutant Shaker Potassium Channels

@article{Zheng1997SelectivityCD,
  title={Selectivity Changes during Activation of Mutant Shaker Potassium Channels },
  author={Jie Zheng and Fred J. Sigworth},
  journal={The Journal of General Physiology},
  year={1997},
  volume={110},
  pages={101 - 117}
}
Mutations of the pore-region residue T442 in Shaker channels result in large effects on channel kinetics. We studied mutations at this position in the backgrounds of NH2-terminal-truncated Shaker H4 and a Shaker -NGK2 chimeric channel having high conductance (Lopez, G.A., Y.N. Jan, and L.Y. Jan. 1994. Nature (Lond.). 367: 179-182). While mutations of T442 to C, D, H, V, or Y resulted in undetectable expression in Xenopus oocytes, S and G mutants yielded functional channels having deactivation… CONTINUE READING

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