Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors.

@article{Gores2012SelectivelyTM,
  title={Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors.},
  author={Gregory J. Gores and Scott H. Kaufmann},
  journal={Genes & development},
  year={2012},
  volume={26 4},
  pages={305-11}
}
Bcl-2, Bcl-x(L), Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-x(L) for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120-125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors… CONTINUE READING