Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.

@article{Boutt2006SelectivelyIO,
  title={Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.},
  author={Angela M. Boutt{\'e} and Randall L. Woltjer and Lisa J. Zimmerman and Sheryl L Stamer and Kathleen S. Montine and Michael V Manno and Patrick J Cimino and Daniel C. Liebler and Thomas J. Montine},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 9},
  pages={1473-83}
}
Deleterious post-translational modifications (PTMs) to the neuronal cytoskeleton are a proposed mechanistic link between accumulation of amyloid (A) beta peptides and subsequent abnormalities of tau and neurodegeneration in Alzheimer's disease (AD). Here we tested the hypothesis that PTMs on neuronal tubulins selectively accumulate in a pathological protein fraction in AD. We used new software, P-MOD, to identify comprehensively and map PTMs using mass spectral data from soluble (normal) and… CONTINUE READING
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