Selectively T cell-depleted allografts from HLA-matched sibling donors followed by low-dose posttransplantation immunosuppression to improve transplantation outcome in patients with hematologic malignancies.

@article{Mielke2011SelectivelyTC,
  title={Selectively T cell-depleted allografts from HLA-matched sibling donors followed by low-dose posttransplantation immunosuppression to improve transplantation outcome in patients with hematologic malignancies.},
  author={Stephan Mielke and Zachariah A McIver and Aarthy Shenoy and Vicki S Fellowes and Hahn M Khuu and David F Stroncek and Susan F. Leitman and Richard W. Childs and Minoo Battiwalla and Eleftheria Koklanaris and Janice Haggerty and Bipin N. Savani and Katy Rezvani and Austin John Barrett},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2011},
  volume={17 12},
  pages={
          1855-61
        }
}
  • S. Mielke, Z. McIver, +11 authors A. Barrett
  • Published 1 December 2011
  • Medicine
  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
We evaluated a photodepletion technique to selectively deplete host-reacting T cells from human leukocyte antigen (HLA)-matched sibling stem cell transplantations with the goal of reducing posttransplantation immunosuppression to improve antimalignancy effects postallografting. Donor lymphocytes were stimulated with irradiated expanded recipient T lymphocytes in an ex vivo mixed lymphocyte reaction. Alloactivated T cells preferentially retaining the photosensitizer 4,5-dibromorhodamine 123… 
Immune reconstitution in recipients of photodepleted HLA-identical sibling donor stem cell transplantations: T cell subset frequencies predict outcome.
  • Z. McIver, J. Melenhorst, +8 authors A. Barrett
  • Medicine
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2011
TLDR
The findings emphasize the role of donor memory T cells and CD4 cells in establishing immune competence post-SCT and make the PD approach used by the group for allodepletion in HLA-matched sibling transplantations an inefficient technique.
Specific removal of alloreactive T-cells to prevent GvHD in hemopoietic stem cell transplantation: rationale, strategies and perspectives.
TLDR
Different approaches to deplete alloreactive T-cells only are reviewed and pros and cons, specificity, efficiency and efficacy are discussed, and Combinations of different methods and innovative approaches are also proposed for depleting specific allore active T- cells with high efficiency.
T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation
TLDR
In vitro strategies and in vivo approaches aimed at preventing GVHD by selectively manipulating key components of the adaptive immune response, such as T-cell receptor (TCR)-αβ T cells and CD45RA-expressing naive T cells are provided.
Selective T-cell depletion for haplotype-mismatched allogeneic stem cell transplantation.
TLDR
Efforts to promote efficient antigen presentation and selective allodepletion promise to accelerate immune reconstitution without GVHD and to address the most crucial issues in haplo-mismatched and other types of transplants.
Selective depletion of alloreactive donor T cells leads to elimination of graft-versus-host reactivity and stimulates graft-versus-leukaemia/myeloma effect.
TLDR
It is possible to selectively deplete donor alloreactive T cells with anti-CD25 immunotoxin to prevent graft-versus-host disease while conserving useful donor immune functions.
Adenosine Selectively Depletes Alloreactive T Cells to Prevent GVHD While Conserving Immunity to Viruses and Leukemia.
TLDR
This study is the first to demonstrate that adenosine depletion of alloactivated T cells maintains a complete immune cell profile and recall viral responses, and opens the possibility of generating T-cell products capable of graft-versus-tumor responses without causing GVHD.
B cells in chronic graft-versus-host disease.
TLDR
Allogeneic hematopoietic stem cell transplantation is the definitive therapy for numerous otherwise incurable hematologic malignancies and non-malignant diseases and emerging evidence has prompted investigation of several small molecule inhibitors in an attempt to restore B cell homeostasis and potentially target rare, pathologic B cell populations.
Allogeneic and Autologous T cell Strategies to Enhance Targeting of Acute Myeloid Leukemias
TLDR
Initial clinical results with mHAG-specific T-cells in transplanted patients show promising disease control but have identified off-target effects of some T-cell infusions, and reveal a tendency for tumor escape.
Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease
TLDR
The high selectivity of this novel photosensitizer may have broad applications and provide alternative treatment options for patients with T lymphocyte–mediated diseases.
Optimization of methodology for production of CD25/CD71 allodepleted donor T cells for clinical use.
TLDR
A methodology for selective depletion of alloreactive T cells after activation with host antigen-presenting cells by targeting T cells up-regulating CD25 and CD71 yields a pool of allodepleted donor T cells with antiviral properties with minimal capacity to cause graft-versus-host disease.
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  • Z. McIver, J. Melenhorst, +8 authors A. Barrett
  • Medicine
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2011
TLDR
The findings emphasize the role of donor memory T cells and CD4 cells in establishing immune competence post-SCT and make the PD approach used by the group for allodepletion in HLA-matched sibling transplantations an inefficient technique.
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