Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging

@article{Sun2007SelectiveVO,
  title={Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging},
  author={Shu-Wei Sun and Hsiao-Fang Liang and Robert E. Schmidt and Anne H. Cross and Sheng-Kwei Song},
  journal={Neurobiology of Disease},
  year={2007},
  volume={28},
  pages={30-38}
}
In this study, axial (lambda(parallel)) and radial (lambda(perpendicular)) diffusivities derived from diffusion tensor imaging (DTI) were used to evaluate white matter injury in brains of mice affected by experimental autoimmune encephalomyelitis (EAE). Sixteen female C57BL/6 mice were immunized with amino acids 35-55 of myelin oligodendrocyte glycoprotein (MOG(35-55)). Three months after immunization, optic nerve and tract were severely affected with 19% and 18% decrease in lambda(parallel… CONTINUE READING

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