Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.

@article{Richfield1994SelectiveVI,
  title={Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.},
  author={Eric K. Richfield and Miles Herkenham},
  journal={Annals of neurology},
  year={1994},
  volume={36 4},
  pages={577-84}
}
Selective neuronal vulnerability is a key feature of the neuropathology of Huntington's disease. We used [3H]CP-55,940, a synthetic cannabinoid, to label cannabinoid receptors in tissue sections from individuals dying with Huntington's disease and from normal control subjects. The density of cannabinoid receptors in striatum and pallidum was measured using quantitative autoradiography. There was a greater loss of cannabinoid receptors on striatal nerve terminals in the lateral pallidum compared… CONTINUE READING

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