Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI

@article{Wingen2007SelectiveVA,
  title={Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI},
  author={Marleen Wingen and Kim P. C. Kuypers and Johannes G Ramaekers},
  journal={Journal of Psychopharmacology},
  year={2007},
  volume={21},
  pages={477 - 485}
}
Serotonergic neurotransmission has been implicated in memory impairment. It is uncLear however if memory performance is mediated through general 5-HT availability, through specific 5-HT receptors or both. The aim of the present study was to assess the contribution of 5-HT reuptake inhibition and specific blockade of 5-HT1A and 5-HT2A receptors to memory impairment. The study was conducted according to a randomized, double-blind, placebo-controlled, four-way cross-over design including 16… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Acute administration of citalopram facilitates memory consolidation in healthy volunteers
TLDR
The results indicate that augmentation of serotonergic neurotransmission is associated with increased memory consolidation, which may be relevant to its therapeutic and cognitive actions in acutely depressed patients. Expand
Role of serotonin in memory impairment
TLDR
Converging evidence suggests that the administration of 5-HT2A/2C or 5- HT4 receptor agonists or5-HT1A or 5HT3 and 5-ht1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand. Expand
Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory.
TLDR
Postsynaptic 5-HT(1A )receptors localized in the hippocampal formation have a negative influence on explicit memory function, which raises the possibility that the antagonistic effect of postsynaptic5-HT (1A) receptors in the hippocampus leads to improvement of human memory function. Expand
Effects of 5-HT on Memory and the Hippocampus: Model and Data
TLDR
The results suggest that the memory impairments in depressed subjects may be related to 5- HT undertransmission, and support the notion that 5-HT1A agonists ameliorate memory deficits in depression. Expand
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
TLDR
Results indicate that serotonin is essential in the process of long-term memory consolidation, primarily in the first 30 min after acquisition, and that improvement of specific cognitive processes by lowered 5-HT function may be linked to the removal of inhibitory actions of 5- HT in the cortex. Expand
Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women
TLDR
The findings suggest that low brain serotonin versus dopamine selectively impairs memory performance in humans, and may shed light on the role of these neurotransmitters in disorders that are characterized by significant memory impairment. Expand
Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected
TLDR
It is concluded that a single dose of MDMA impairs spatial memory for location but leaves processing of contextual information intact. Expand
Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation
TLDR
It is concluded that tryptophan depletion specifically impairs long-term memory formation, presumably as a result of an acute decrease in 5-HT turnover in the brain. Expand
Involvement of 5-HT2A/2B/2C Receptors on Memory Formation: Simple Agonism, Antagonism, or Inverse Agonism?
  • A. Meneses
  • Psychology, Medicine
  • Cellular and Molecular Neurobiology
  • 2004
Abstract1. The 5-HT2 receptors subdivision into the 5-HT2A/2B/2C subtypes along with the advent of the selective antagonists has allowed a more detailed investigation on the role and therapeuticExpand
Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
TLDR
Results showed that a single dose of MDMA caused impairment of immediate and delayed recall on a verbal learning task during the intoxication phase, however, there was no residual memory impairment during the withdrawal phase. Expand
...
1
2
3
4
5
...