Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71.

@article{Urasawa2008SelectiveVD,
  title={Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71.},
  author={Nobuyuki Urasawa and Michiko R Wada and Noboru Machida and Katsutoshi Yuasa and Yoshiki Shimatsu and Yoshito Wakao and Shigeki Yuasa and Toshiaki Sano and Ikuya Nonaka and Akinori Nakamura and Shin'ichi Takeda},
  journal={Circulation},
  year={2008},
  volume={117 19},
  pages={2437-48}
}
BACKGROUND Respiratory support therapy significantly improves life span in patients with Duchenne muscular dystrophy; cardiac-related fatalities, including lethal arrhythmias, then become a crucial issue. It is therefore important to more thoroughly understand cardiac involvement, especially pathology of the conduction system, in the larger Duchenne muscular dystrophy animal models such as dystrophic dogs. METHODS AND RESULTS When 10 dogs with canine X-linked muscular dystrophy in Japan (CXMD… CONTINUE READING

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