Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.

  title={Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.},
  author={Esra Cagavi Bozkulak and Gerry Weinmaster},
  journal={Molecular and cellular biology},
  volume={29 21},
Notch signaling requires a series of proteolytic cleavage events to release the Notch intracellular domain (NICD) that functions directly in signal transduction. The Notch receptor is locked down in a protease-resistant state by a negative regulatory region (NRR) that protects an ADAM (a disintegrin and metalloprotease) cleavage site. Engagement with ligand-bearing cells induces global conformational movements in Notch that unfold the NRR structure to expose the ADAM cleavage site and initiate… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS